Electronic health records (EHRs) support powerful clinical prediction models, but existing methods typically provide coarse, post hoc explanations that offer limited value for patient-level decision making. We introduce a knowledge graph (KG)-guided chain-of-thought (CoT) framework that generates clinically grounded and temporally consistent reasoning for visit-level disease prediction in MIMIC-III. ICD-9 codes are mapped to PrimeKG, from which disease-relevant nodes and multi-hop reasoning paths are extracted and used as scaffolds for CoT generation; only explanations whose conclusions match observed outcomes are retained. Lightweight LLaMA-3.1-Instruct-8B and Gemma-7B models are then fine-tuned on this supervision corpus. Across ten PrimeKG-mapped diseases and limited training cohorts (400 and 1000 cases), KG-guided models outperform strong classical baselines, achieving AUROC values of 0.66 to 0.70 and macro-AUPR values of 0.40 to 0.47. The models also transfer zero-shot to the CRADLE cohort, improving accuracy from approximately 0.40 to 0.51 up to 0.72 to 0.77. A blinded clinician evaluation shows consistent preference for KG-guided CoT explanations in clarity, relevance, and clinical correctness.

Early prediction of pediatric cardiac arrest (CA) is critical for timely intervention in high-risk intensive care settings. We introduce PedCA-FT, a novel transformer-based framework that fuses tabular view of EHR with the derived textual view of EHR to fully unleash the interactions of high-dimensional risk factors and their dynamics. By employing dedicated transformer modules for each modality view, PedCA-FT captures complex temporal and contextual patterns to produce robust CA risk estimates. Evaluated on a curated pediatric cohort from the CHOA-CICU database, our approach outperforms ten other artificial intelligence models across five key performance metrics and identifies clinically meaningful risk factors. These findings underscore the potential of multimodal fusion techniques to enhance early CA detection and improve patient care.

We demonstrate the Patterns of Life Simulation to create realistic simulations of human mobility in a city. This simulation has recently been used to generate massive amounts of trajectory and check-in data. Our demonstration focuses on using the simulation twofold: (1) using the graphical user interface (GUI), and (2) running the simulation headless by disabling the GUI for faster data generation. We further demonstrate how the Patterns of Life simulation can be used to simulate any region on Earth by using publicly available data from OpenStreetMap. Finally, we also demonstrate recent improvements to the scalability of the simulation allows simulating up to 100,000 individual agents for years of simulation time. During our demonstration, as well as offline using our guides on GitHub, participants will learn: (1) The theories of human behavior driving the Patters of Life simulation, (2) how to simulate to generate massive amounts of synthetic yet realistic trajectory data, (3) running the simulation for a region of interest chosen by participants using OSM data, (4) learn the scalability of the simulation and understand the properties of generated data, and (5) manage thousands of parallel simulation instances running concurrently.

Electronic Health Records (EHRs) contain rich patient information and are crucial for clinical research and practice. In recent years, deep learning models have been applied to EHRs, but they often rely on massive features, which may not be readily available for all patients. We propose HTP-Star, which leverages hypergraph structures with a pretrain-then-finetune framework for modeling EHR data, enabling seamless integration of additional features. Additionally, we design two techniques, namely (1) Smoothness-inducing Regularization and (2) Group-balanced Reweighting, to enhance the model's robustness during fine-tuning. Through experiments conducted on two real EHR datasets, we demonstrate that HTP-Star consistently outperforms various baselines while striking a balance between patients with basic and extra features.

Individuals and organizations are still struggling with how and how much to integrate AI into daily life. Rarely has that been more clear than a case out of Emory University in which the school went from awarding students with an entrepreneurship prize worth 10,000 for their AI-powered studying tool to suspending them for it, 404 Media reports. No, the students didn't suddenly misuse the tool, known as Eightball, in any way; they did just as they said they would, and all the while, Emory promoted them -- until they didn't. Eightball allowed students to turn any coursework or readings into practice tests or flashcards for studying. It also connected to Canvas -- the platform professors at Emory use to share course documents with their students.

Linking (aligning) biomedical concepts across diverse data sources enables various integrative analyses, but it is challenging due to the discrepancies in concept naming conventions. Various strategies have been developed to overcome this challenge, such as those based on string-matching rules, manually crafted thesauri, and machine learning models. However, these methods are constrained by limited prior biomedical knowledge and can hardly generalize beyond the limited amounts of rules, thesauri, or training samples. Recently, large language models (LLMs) have exhibited impressive results in diverse biomedical NLP tasks due to their unprecedentedly rich prior knowledge and strong zero-shot prediction abilities. However, LLMs suffer from issues including high costs, limited context length, and unreliable predictions. In this research, we propose PromptLink, a novel biomedical concept linking framework that leverages LLMs. It first employs a biomedical-specialized pre-trained language model to generate candidate concepts that can fit in the LLM context windows. Then it utilizes an LLM to link concepts through two-stage prompts, where the first-stage prompt aims to elicit the biomedical prior knowledge from the LLM for the concept linking task and the second-stage prompt enforces the LLM to reflect on its own predictions to further enhance their reliability. Empirical results on the concept linking task between two EHR datasets and an external biomedical KG demonstrate the effectiveness of PromptLink. Furthermore, PromptLink is a generic framework without reliance on additional prior knowledge, context, or training data, making it well-suited for concept linking across various types of data sources. The source code is available at https://github.com/constantjxyz/PromptLink.

In this study, we present a deep learning framework designed to integrate with our previously developed system that facilitates large-scale 1D fetal Doppler data collection, aiming to enhance data quality. This system, tailored for traditional Indigenous midwives in low-resource communities, leverages a cost-effective Android phone to improve the quality of recorded signals. We have shown that the Doppler data can be used to identify fetal growth restriction, hypertension, and other concerning issues during pregnancy. However, the quality of the signal is dependent on many factors, including radio frequency interference, position of the fetus, maternal body habitus, and usage of the Doppler by the birth attendants. In order to provide instant feedback to allow correction of the data at source, a signal quality metric is required that can run in real-time on the mobile phone. In this study, 191 DUS signals with durations mainly in the range between 5 to 10 minutes were evaluated for quality and classified into five categories: Good, Poor, (Radiofrequency) Interference, Talking, and Silent, at a resolution of 3.75 seconds. A deep neural network was trained on each 3.75-second segment from these recordings and validated using five-fold cross-validation. An average micro F1 = 97.4\% and macro F1 = 94.2\% were achieved, with F1 = 99.2\% for `Good' quality data. These results indicate that the algorithm, which will now be implemented in the midwives' app, should allow a significant increase in the quality of data at the time of capture.

Globally, there has been a significant increase in the number of people using prescription drugs for reasons other than why they were prescribed, sometimes combining them with other substances such as alcohol to sleep better or stimulants to perform better. A team of computer scientists and emergency physicians from Emory, Oregon, and Pennsylvania universities in the United States used AI to analyze drug misuse and the emotions users felt during times of use. The study, "Large-Scale Social Media Analysis Reveals Emotions Associated with Nonmedical Prescription Drug Use," was published in the journal Health Data Science. In 2021, more than 108,000 people in the U.S. died from drug overdoses, a number that is up 20% from 2020, many of these deaths were caused by the ingestion of prescription drugs, often mixed with other substances. In France, more than 10,000 people die each year as a result of medication misuse.

Ever wondered what your dog is thinking when it gazes at the TV, seemingly fascinated by the News At Ten? Scientists have discovered that your pooch probably isn't focused on Huw Edwards specifically, but more what the people on screen are doing. Study dogs at Emory University in Georgia, USA had their brains scanned by an MRI machine while watching a half-hour video of stimulating content. This included clips of dogs running around, humans interacting with each other, vehicles passing by, and a cat in a house. Data from the MRI was fed into an artificial intelligence (AI) called Ivis, which correlated brain activity with whether an action or object was shown on screen. Results showed that dogs are vastly more visually attuned to actions in their environment, rather than who or what is performing those actions.

Amazon is cracking down price gougers on its platform who are looking to make a profit from the coronavirus that is wreaking havoc across the globe. The tech giant has pulled more than 530,000 listings from the site and suspended over 2,500 US sellers. The firm announced on Friday it is working with state attorneys general to identify and prosecute third-party sellers who are taking advantage of fears of the spreading coronavirus to engage in price-gouging on the Amazon website. Amazon also said it has begun manual audits of products in its online stores to spot sellers that evade its automated systems, which check for items that are'unfairly priced.' Amazon is cracking down price gougers on its platform who are looking to make a profit from the coronavirus that is wreaking havoc across the globe.